Principal Investigator | Tyrrell Laboratory
University of Alabama at Birmingham, Birmingham, AL
I lead a research lab that combines wet-lab and dry-lab approaches to investigate aging-specific disease mechanisms. We use advanced single-cell technologies, spectral flow cytometry, and computational biology to understand how age impacts chronic inflammatory diseases. The strongest risk factor for nearly all chronic diseases from cardiovascular disease, dementia, and most cancers is a person's age. While we cannot modify how old you are, we hope we can one day modify the biological changes that occur as we get older. Thus, my lab focuses on identifying and understanding the biological changes that happen during aging that contribute to disease.
Computational tools and analyses from our lab
First comprehensive single-cell analysis revealing coordinated age-dependent interactions between microglia and T cells in neuroinflammation, uncovering novel mechanisms of brain aging.
User-friendly web application that democratizes high-dimensional spectral flow cytometry analysis, making advanced immunological analysis accessible without extensive computational expertise.
Comprehensive computational pipeline enabling unprecedented characterization of complex immune cell populations and landscapes in disease states using spectral flow cytometry.
Comprehensive analysis of NIH Pathway to Independence Awards (2006-2022) revealing how institutional prestige and gender impact career trajectories and funding success.
Understanding the intersection of aging and disease through integrative approaches
Investigating age-dependent neuroinflammatory circuits and microglia-T cell interactions in the brain using single-cell approaches.
Understanding vascular inflammation and age-related cardiovascular disease development through advanced imaging and genomics.
Exploring immune dysregulation mechanisms in aging-associated autoimmune conditions using murine models.
Characterizing cytotoxic T cell contributions to chronic inflammatory diseases with spectral flow cytometry.
We're always looking for motivated researchers interested in aging, immunology, and single-cell analysis
Heersink School of Medicine
University of Alabama at Birmingham
Birmingham, AL